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Millipore
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Image Search Results
Journal:
Article Title: Fragile-X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid
doi: 10.1523/JNEUROSCI.3660-10.2010
Figure Lengend Snippet: (A) Schematic of the 3xDR5-RARE-GFP reporter construct. (B) Representative images of RARE-GFP reporter expression in WT and KO neurons with and without 24 hours TTX+APV treatment. Scale bar, 10 μm. (C) Quantification of B (n = 16-18; *, p<0.05). (D) Representative traces and quantification of mEPSC amplitude in WT and KO neurons after four hours DMSO or RA treatment (n = 31-33; ***, p<0.001). Philanthotoxin-433 was used to block GluR2-lacking AMPA receptor-mediated responses in WT-RA group (n = 22). Scale bar: 10 pA, 40 ms. (E) Effect of transcription inhibitor Actinomycin D and translation inhibitor cycloheximide on RA-induced synaptic scaling in WT neurons (n = 22-27; ***, p<0.001). Error bars represent SEM.
Article Snippet: Drugs and Chemicals The following drugs and chemicals were purchased from
Techniques: Construct, Expressing, Blocking Assay
Journal:
Article Title: Fragile-X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid
doi: 10.1523/JNEUROSCI.3660-10.2010
Figure Lengend Snippet: (A) 60 hours of TTX induced synaptic scaling in WT and KO neurons. Philanthotoxin-433 was used to block GluR2-lacking AMPA receptor-mediated responses. (n = 18-39; **, p<0.01; ***, p<0.001). (B) Representative images of RARE-GFP reporter expression in WT and KO neurons with and without 48 hours TTX treatment. Scale bar, 10 μm. (C) Quantification of B (n = 22-28). (D) Effect of RA synthesis blocker DEAB on 60 hour TTX-induced synaptic scaling and 36 hour TTX+APV-induced scaling (n = 21-27; ***, p < 0.001). Error bars represent SEM.
Article Snippet: Drugs and Chemicals The following drugs and chemicals were purchased from
Techniques: Blocking Assay, Expressing